Endurance training affects myosin heavy chain phenotype in regenerating fast-twitch muscle.

Difference between Myosin Light and Heavy Chain Isoforms Patterns in Fast- and Slow-twitch Skeletal Muscle: Effect of Endurance Training

Myosin content of individual human muscle fibers isolated by laser capture microdissection.

Muscle fiber composition correlates with insulin resistance, and exercise training can increase slow-twitch (type I) fibers and, thereby, mitigate diabetes risk. Human skeletal muscle is made up of three distinct fiber types, but muscle contains many more isoforms of myosin heavy and light chains, which are coded by 15 and 11 different genes, respectively. Laser capture microdissection techniqu...

Expression of slow myosin heavy chain during muscle regeneration is not always dependent on muscle innervation and calcineurin phosphatase activity.

In the literature, there is an ambiguity as to the respective roles played by calcineurin phosphatase activity (CPA) and muscle innervation in the reestablishment of the slow-twitch muscle phenotype after muscle regeneration in different species. In this study, we wanted to determine the role of calcineurin and muscle innervation on the appearance and maintenance of the slow phenotype during mo...

Single muscle fiber contractile properties of young competitive distance runners.

The purpose of this investigation was to characterize the contractile properties of individual slow- and fast-twitch myofibers from highly trained distance runners. Muscle biopsies were obtained from the gastrocnemius of eight competitive runners (Run) and eight recreationally active individuals (Rec). Slow-twitch [myosin heavy chain (MHC) I] and fast-twitch (MHC IIa) myofibers were isolated an...

Improvement in Walking Distance after Rehabilitation in Patients with Peripheral Arterial Disease is Associated with Changes in Skeletal Muscle Myosin Heavy Chains

Intermittent claudication in peripheral arterial disease limits exercise capacity. Rehabilitation can produce an improvement in absolute walking distance. Very often changes in skeletal muscle, rather than changes in blood flow, are responsible for the improved exercise capacity. We studied 8 patients with intermittent claudication (Fontaine 2 class) that underwent a 4week treadmill mild-modera...